Article

Discovery of cancer driver genes based on nucleotide context

2018-12-04

Abstract excerpt

Many cancer genomes contain large numbers of somatic mutations, but few of these mutations drive tumor development. Current approaches to identify cancer driver genes are largely based on mutational recurrence, i.e. they search for genes with an increased number of nonsynonymous mutations relative to the local background mutation rate. Multiple studies have noted that the sensitivity of recurrence-based methods is...

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Literature Corpus work: 38173e8f-09a2-54bd-a8c0-804d49e98379
DOI: 10.1101/485292

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