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Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia

27 Nov 2023

Abstract excerpt

During the last decades, remarkable progress has been made in further understanding the complex molecular regulatory networks that maintain hematopoietic stem cell (HSC) function. Cellular and organismal metabolisms have been shown to directly instruct epigenetic alterations, and thereby dictate stem cell fate, in the bone marrow. Epigenetic regulatory enzymes are dependent on the availability of metabolites to...

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PMID: 38010205
DOI: 10.15252/embj.2022112348

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