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Novel insights into PARPs in gene expression: regulation of RNA metabolism

4 May 2019

Abstract excerpt

Poly(ADP-ribosyl)ation (PARylation) is an important post-translational modification in which an ADP-ribose group is transferred to the target protein by poly(ADP-riboses) polymerases (PARPs). Since the discovery of poly-ADP-ribose (PAR) 50 years ago, its roles in cellular processes have been extensively explored. Although research initially focused on the functions of PAR and PARPs in DNA damage detection and...

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PMID: 31055645
DOI: 10.1007/s00018-019-03120-6

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