Article

Cryo-EM Structures of Four Polymorphic TDP-43 Amyloid Cores

2019-04-06

Abstract excerpt

<h4>Summary Paragraph</h4> TDP-43 is an essential DNA/RNA processing protein that undergoes both functional and pathogenic aggregation. Functional TDP-43 aggregates are reversible, forming transient species such as nuclear bodies, stress granules, and myo-granules 1–3 . In contrast pathogenic TDP-43 aggregates are irreversible, forming stable intracellular amyloid-like inclusions 4,5 . These inclusions are the...

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Literature Corpus work: 26000659-1958-5cca-bfbb-32094dcc5e99
DOI: 10.1101/601120

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