Article

Gel-like inclusions of C-terminal fragments of TDP-43 sequester and inhibit proteasomes in neurons

2021-03-16

Abstract excerpt

TDP-43 inclusions enriched in C-terminal fragments of ~25kDa (“TDP-25”) are associated with neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we analyzed gain-of-function mechanisms of TDP-25 combining cryo-electron tomography, proteomics and functional assays. TDP-25 inclusions are amorphous with gel-like biophysical properties and sequester proteasomes adopting exc...

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Literature Corpus work: 82e3d975-f1cf-5886-8efd-ea064f2ab3f4
DOI: 10.1101/2021.03.15.435268

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