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Bio-synthesis of <sup>15</sup> N-Labeled G-Quadruplexes to Investigate the Structure and Interactions in the Cell Lysate using Nuclear Magnetic Resonance

2025-11-04

Abstract excerpt

G-quadruplexes (G4) play key roles in biology, making it critical to understand their structure and ligand-binding behavior in cellular environments for advancing G4-targeted therapeutics. While in-cell nuclear magnetic resonance (NMR) is a powerful technique for studying G4 in situ, its application is limited by the challenge of producing isotope-labeled single-stranded DNA (ssDNA). Here, we introduce Restriction...

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Literature Corpus work: 183ed67e-3a48-5fa5-bd1a-62a13a34f577
DOI: 10.1101/2025.11.03.685478

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Bio-synthesis of <sup>15</sup> N-Labeled G-Quadruplexes to Investigate the Structure and Interactions in the Cell Lysate using Nuclear Magnetic ResonanceDOI 10.1101/2025.11.03.685478Read

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