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Article

Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C.

Scientific reports - 29 Mar 2021

Rahman Samiur, Beikzadeh Mahtab, Latham Michael P

Abstract excerpt

The MRE11-RAD50-NBS1 (MRN) protein complex plays a vital role in DNA double strand break sensing, signaling, and repair. Mutation in any component of this complex may lead to disease as disrupting DNA double strand break repair has the potential to cause translocations and loss of genomic information. Here, we have investigated an MRE11 mutation, F237C, identified in a breast cancer tumor. We found that the...

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Source

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Identifiers

PMID: 33782469
DOI: 10.1038/s41598-021-86552-0
PMCID: PMC8007570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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