Article

Monitoring DNA-Ligand Interactions in Living Human Cells Using High-Resolution NMR Spectroscopy

2019-05-10

Abstract excerpt

High-resolution studies of DNA–ligand interactions in the cellular environment are problematic due to the lack of suitable biophysical tools. To address this issue, we developed an in-cell NMR-based approach for monitoring DNA–ligand interactions inside the nuclei of living human cells. Our method relies on the acquisition of high-resolution NMR data of cells electroporated with pre-formed DNA-ligand complex. The...

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Literature Corpus work: 368d8ebb-b314-5351-baef-5241ee44fab9
DOI: 10.26434/chemrxiv.8107772.v1

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