Article

Development of the 12-Base Short Dimeric Myogenetic Oli-godeoxynucleotide That Induces Myogenic Differentiation

2024-03-16

Abstract excerpt

A myogenetic oligodeoxynucleotide (myoDN), iSN04 (5’-AGA TTA GGG TGA GGG TGA-3’), is a single-stranded 18-base telomeric DNA that serves as an anti-nucleolin aptamer and induces myogenic differentiation, which is expected to be a nucleic acid drug for the prevention of disease-associated muscle wasting. To improve the drug efficacy and synthesis cost of myoDN, shortening the sequence while maintaining its structur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fcf7488-e90a-5a54-a51d-7af8a1089767
DOI: 10.1101/2024.03.14.584904

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Development of the 12-Base Short Dimeric Myogenetic Oli-godeoxynucleotide That Induces Myogenic DifferentiationDOI 10.1101/2024.03.14.584904Read

Research and Development of Oligonucleotide Therapeutics in Japan for Rare DiseasesSemantic proximity Read

Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitusSemantic proximity Read

Design and Analysis of Effects of Triplet Repeat Oligonucleotides in Cell Models for Myotonic DystrophySemantic proximity Read

Delivery of a chemically modified noncoding RNA domain improves dystrophic myotube functionSemantic proximity Read

DNA repair byproduct 8-oxoguanine base promotes myogenic differentiation via OGG1-mediated activation of RAS-MEK-MyoD signaling pathwaySemantic proximity Read

Palmitic acid conjugation enhances potency of tricyclo-DNA splice switching oligonucleotidesSemantic proximity Read

G-quadruplex ligands mediate downregulation of DUX4 expressionSemantic proximity Read

Bridged Nucleic Acids ReloadedSemantic proximity Read

Bio-synthesis of <sup>15</sup> N-Labeled G-Quadruplexes to Investigate the Structure and Interactions in the Cell Lysate using Nuclear Magnetic ResonanceSemantic proximity Read

Design of highly efficient and selective transfer reaction of nitrosyl group to dc and d(M)C resulting in specific deamination.Semantic proximity Read

Ribozyme-mediated trans-splicing of a trinucleotide repeatSemantic proximity Read