Article

Genome-wide association study of enlarged perivascular spaces: results from two large population-based cohorts

2025-09-12

Abstract excerpt

Enlarged perivascular spaces (PVS) are markers of cerebral small vessel disease (cSVD), implicated in neurovascular and neurodegenerative processes. We conducted a genome-wide association study (GWAS) of quantitative, global PVS volume using brain MRI data from UK Biobank and the Rhineland Study. The meta-analysis (n = 43,050) identified 54 genome-wide significant loci, including 39 novel loci, implicating vascula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c718a6e-a817-5e1a-a220-95beba7004e6
DOI: 10.1101/2025.09.09.25335402

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study of enlarged perivascular spaces: results from two large population-based cohortsDOI 10.1101/2025.09.09.25335402Read

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel diseaseSemantic proximity Read

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel diseaseSemantic proximity Read

Cerebral small vessel disease genomics and its implications across the lifespanSemantic proximity Read

Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable.Semantic proximity Read

Clinical Phenotypes Associated With Cerebral Small Vessel Disease: A Study of 45,013 UK Biobank Participants.Semantic proximity Read

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel diseaseSemantic proximity Read

Genomics of diffusion-imaging integrating GWAS, exome data and single-cell sequencing unravels lifespan determinants of cerebral small vessel diseaseSemantic proximity Read

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.Semantic proximity Read

Human brain vascular multi-omics elucidates disease-risk associations.Semantic proximity Read

Body mass index, time of day, and genetics affect perivascular spaces in the white matterSemantic proximity Read

Enlarged Perivascular Spaces are Associated with White Matter Injury, Brain Atrophy, Cognitive Decline and Markers of Inflammation in an Autosomal Dominant Vascular Neurodegenerative Disease (CADASIL)Semantic proximity Read

A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease riskSemantic proximity Read