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Article

Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease.

Molecular psychiatry - 1 Nov 2024

Le Grand Quentin, Tsuchida Ami, Koch Alexandra, Imtiaz Mohammed-Aslam, Aziz N Ahmad, Vigneron Chloé, Zago Laure, Lathrop Mark, Dubrac Alexandre, Couffinhal Thierry, Crivello Fabrice, Matthews Paul M, Mishra Aniket, Breteler Monique M B, Tzourio Christophe, Debette Stéphanie

Abstract excerpt

Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were recently shown to be significantly associated with white matter (WM) microstructure on diffusion tensor imaging (signal-based) in young adults. To provide new insights into these early changes in WM microstructure and their...

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Identifiers

PMID: 38811690
DOI: 10.1038/s41380-024-02604-7
PMCID: PMC11541005

Genes

STAT3
VCAN

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