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Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity

2022-06-22

Abstract excerpt

<h4>Background: </h4> Noradrenergic neurons in the locus coeruleus (LC) are the primary source of norepinephrine (NE) in the brain and degeneration of these neurons is reported in the early stages of Parkinson’s disease (PD), even prior to dopaminergic neuron degeneration in the substantia nigra (SN), which is a hallmark of PD pathology. NE depletion is generally associated with increased PD pathology in neurotoxi...

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Literature Corpus work
18183cd8-fc02-52ca-b659-f6f8135b99f9
DOI
10.21203/rs.3.rs-1766396/v1
Open publication

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Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicityDOI 10.21203/rs.3.rs-1766396/v1
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