Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

doi:10.1186/1742-2094-4-8

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Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

Journal of neuroinflammation - 26 Feb 2007

Pugh Perdita L, Vidgeon-Hart Martin P, Ashmeade Tracey, Culbert Ainsley A, Seymour Zoe, Perren Marion J, Joyce Flora, Bate Simon T, Babin Anna, Virley David J, Richardson Jill C, Upton Neil, Sunter David

Abstract excerpt

BACKGROUND: Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC has projections to brain regions vulnerable to amyloid deposition and lack of LC derived NA could play a role in the...

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PMID: 17324270
DOI: 10.1186/1742-2094-4-8
PMCID: PMC1810243

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Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.PMID 17324270Read ↗

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