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Article

A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.

Acta neuropathologica communications - 10 May 2018

Henrich Martin Timo, Geibl Fanni Fruzsina, Lee Bolam, Chiu Wei-Hua, Koprich James Benjamin, Brotchie Jonathan Michael, Timmermann Lars, Decher Niels, Matschke Lina Anita, Oertel Wolfgang Hermann

Abstract excerpt

Degeneration of noradrenergic locus coeruleus neurons occurs during the prodromal phase of Parkinson's disease and contributes to a variety of non-motor symptoms, e.g. depression, anxiety and REM sleep behavior disorder. This study was designed to establish the first locus coeruleus α-synucleinopathy mouse model, which should provide sufficient information about the time-course of noradrenergic neurodegeneration,...

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Identifiers

PMID: 29747690
DOI: 10.1186/s40478-018-0541-1
PMCID: PMC5946574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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