Article

Quantification of T- and B-cell immune receptor distribution diversity characterizes immune cell infiltration and lymphocyte heterogeneity in clear cell renal cell carcinoma

2021-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Immune-modulating systemic therapies are often used to treat advanced cancer such as metastatic clear cell renal cell carcinoma (ccRCC). Used alone, sequence-based biomarkers neither accurately capture patient dynamics nor the tumor immune microenvironment. To better understand the tumor ecology of this immune microenvironment, we quantified tumor infiltration across two distinct ccRCC patient tu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 180361f8-6a28-5b58-afdc-a7776e5b8371
DOI: 10.1101/2021.06.15.21258987

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantification of T- and B-cell immune receptor distribution diversity characterizes immune cell infiltration and lymphocyte heterogeneity in clear cell renal cell carcinomaDOI 10.1101/2021.06.15.21258987Read

Mapping the Immune Landscape of Clear Cell Renal Cell Carcinoma by Single-Cell RNA-seqSemantic proximity Read

High intratumoral heterogeneity in clear cell renal cell carcinoma is associated with reduced immune response and survivalSemantic proximity Read

Mapping the immune environment in clear cell renal carcinoma by single-cell genomicsSemantic proximity Read

Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escapeSemantic proximity Read

Deep visual multi-omics profiling reveals mechanisms that underlie cancer cell differentiation and aggressiveness in clear cell renal cell carcinomaSemantic proximity Read

Prognostic Immunophenotyping Clusters of Clear Cell Renal Cell Carcinoma Defined by the Unique Tumor Immune MicroenvironmentSemantic proximity Read

Immune Phenotype-Genotype Associations in Primary Clear Cell Renal Cell Carcinoma and Matched Metastatic Tissue.Semantic proximity Read

The differentiation and functional landscape of tumor-resident CD8 <sup>+</sup> T cells shapes immunity and clinical outcomes in clear cell renal cell carcinomaSemantic proximity Read

Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma.Semantic proximity Read

A spatial multi-omic portrait of survival outcome for clear cell renal cell carcinomaSemantic proximity Read

Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signaturesSemantic proximity Read

Clonal architectures predict clinical outcome in clear cell renal cell carcinomaSemantic proximity Read