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Article

High intratumoral heterogeneity in clear cell renal cell carcinoma is associated with reduced immune response and survival

1 May 2025

Abstract excerpt

Background: Clear cell renal cell carcinoma (ccRCC) exhibits high intratumor heterogeneity (ITH), which drives progression, metastasis, and treatment resistance. Nevertheless, clinically applicable tools for predicting patient prognosis based on ITH remain unavailable, and the association between ITH and immune cell response is a matter of debate. The objective of this study was to establish ITH as a clinically...

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PMID: 40529021
DOI: 10.21037/tau-2024-741

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