Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma.

doi:10.1016/j.euf.2021.04.014

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Article

Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma.

European urology focus - 1 May 2022

Chakiryan Nicholas H, Hajiran Ali, Kim Youngchul, Aydin Ahmet M, Zemp Logan, Katende Esther, Nguyen Jonathan, Fan Wenyi, Cheng Chia-Ho, Lopez-Blanco Neale, Chahoud Jad, Spiess Philippe E, Fournier Michelle, Dhillon Jasreman, Wang Liang, Moran-Segura Carlos, Mulé James, Du Dongliang, Yoder Sean J, Berglund Anders, Teer Jamie K, Manley Brandon J

Abstract excerpt

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) tumors have low frequencies of genetic alterations compared with other malignancies, but very high levels of immune cell infiltration and favorable response rates to immunotherapy. Currently, the interplay between specific ccRCC somatic mutations and immune infiltration pattern is unclear. OBJECTIVE: To analyze the associations between common ccRCC somatic...

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Identifiers

PMID: 33994165
DOI: 10.1016/j.euf.2021.04.014
PMCID: PMC11091541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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