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Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

27 Jan 2021

Abstract excerpt

Abstract Clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor types due to high response rate to immunotherapies, despite low tumor mutational burden. To characterize the tumor immune microenvironment of ccRCC, we applied single-cell-RNA sequencing (SCRS) along with T-cell-receptor (TCR) sequencing to map the transcriptomic heterogeneity of 25,688 individual CD45 + lymphoid...

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PMID: 33504936
DOI: 10.1038/s42003-020-01625-6

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