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Article

Immune Phenotype-Genotype Associations in Primary Clear Cell Renal Cell Carcinoma and Matched Metastatic Tissue.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2024

Sobottka Bettina, Vetter Viola, Banaei-Esfahani Amir, Nowak Marta, Lorch Anja, Sirek Andrej, Mertz Kirsten D, Brunelli Matteo, Berthold Dominik, de Leval Laurence, Kahraman Abdullah, Koelzer Viktor Hendrik, Moch Holger

Abstract excerpt

Adjuvant immunotherapy has been recently recommended for patients with metastatic clear cell renal cell carcinoma (ccRCC), but there are no tissue biomarkers to predict treatment response in ccRCC. Potential predictive biomarkers are mainly assessed in primary tumor tissue, whereas metastases (METs) remain understudied. To explore potential differences between genomic alterations and immune phenotypes in primary...

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Source

Identifiers

PMID: 38969270
DOI: 10.1016/j.modpat.2024.100558

Genes

TOX
BAP1
CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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