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The differentiation and functional landscape of tumor-resident CD8 <sup>+</sup> T cells shapes immunity and clinical outcomes in clear cell renal cell carcinoma

2026-03-15

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is a common and lethal kidney cancer in which CD8 + T cell–targeted immunotherapies are standard of care. However, tumor CD8 + T cell infiltration correlates with divergent clinical outcomes, reflecting functional heterogeneity. We comprehensively characterized tumor-specific memory CD8 + T cells in ccRCC using phenotypic, transcriptional and functional analyses. Three ma...

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Literature Corpus work
91bb891e-35e3-5b5f-84a0-2af3fb3e5e66
DOI
10.64898/2026.03.12.711359
Open publication

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