Article

Replication of DNA containing trinucleotide repeats by the bacteriophage T7 replisome

2024-11-18

Abstract excerpt

Trinucleotide repeats in the human genome are implicated in various neurodegenerative diseases. The tendency of these repetitive DNA sequences to form non-B DNA structures can cause abnormal replication, leading to genomic instability. This instability contributes to disease progression, though the underlying mechanisms are not fully understood. We investigated the replication of DNA containing CAG and CTG trinucl...

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Literature Corpus work: 17fcfa3c-d6f2-539e-a9dd-3930a49a556e
DOI: 10.1101/2024.11.17.624010

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