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Article

Mechanism for CCC DNA synthesis in hepadnaviruses.

PloS one - 30 Nov 2009

Sohn Ji A, Litwin Samuel, Seeger Christoph

Abstract excerpt

Hepadnavirus replication requires the synthesis of a covalently closed circular (CCC) DNA from the relaxed circular (RC) viral genome by an unknown mechanism. CCC DNA formation could require enzymatic activities of the viral reverse transcriptase (RT), or cellular DNA repair enzymes, or both. Physical mapping of the 5' and 3' ends of RC DNA and sequence analysis of CCC DNA revealed that CCC DNA synthesis requires...

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Identifiers

PMID: 19956651
DOI: 10.1371/journal.pone.0008093
PMCID: PMC2778999

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