Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expansion of CTG repeats from human disease genes is dependent upon replication mechanisms in Escherichia coli: the effect of long patch mismatch repair revisited.

Journal of molecular biology - 26 Jun 1998

Schumacher S, Fuchs R P, Bichara M

Abstract excerpt

Many human hereditary disease genes have been recently associated with the expansion of CTG/GAC repeats. We have used a plasmid-based assay in Escherichia coli to investigate the instability of a (CTG/GAC) insert containing 64 repeats. Using this assay, expansions were biochemically detected and...

Topics

Cell Survival
DNA Repair
DNA Replication
Escherichia coli
Gene Deletion
Genetic Diseases, Inborn
Genetic Vectors
Humans
Mutation
Trinucleotide Repeats

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9642087
DOI: 10.1006/jmbi.1998.1827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9642087-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expansion of CTG repeats from human disease genes is dependent upon replication mechanisms in Escherichia coli: the effect of long patch mismatch repair revisited.PMID 9642087Read ↗

Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases.Semantic proximity Read ↗

Length of CTG.CAG repeats determines the influence of mismatch repair on genetic instability.Semantic proximity Read ↗

The Startling Role of Mismatch Repair in Trinucleotide Repeat Expansions.Semantic proximity Read ↗

In vitro (CTG)*(CAG) expansions and deletions by human cell extracts.Semantic proximity Read ↗

The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions.Semantic proximity Read ↗

Environmental stress induces trinucleotide repeat mutagenesis in human cells.Semantic proximity Read ↗

Mechanisms of DNA expansion.Semantic proximity Read ↗

DM2 CCTG*CAGG repeats are crossover hotspots that are more prone to expansions than the DM1 CTG*CAG repeats in Escherichia coli.Semantic proximity Read ↗

Genetic instabilities of (CCTG).(CAGG) and (ATTCT).(AGAAT) disease-associated repeats reveal multiple pathways for repeat deletion.Semantic proximity Read ↗

Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.Semantic proximity Read ↗

Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cellsSemantic proximity Read ↗

Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.