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Article

Expansion of CTG repeats from human disease genes is dependent upon replication mechanisms in Escherichia coli: the effect of long patch mismatch repair revisited.

Journal of molecular biology - 26 Jun 1998

Schumacher S, Fuchs R P, Bichara M

Abstract excerpt

Many human hereditary disease genes have been recently associated with the expansion of CTG/GAC repeats. We have used a plasmid-based assay in Escherichia coli to investigate the instability of a (CTG/GAC) insert containing 64 repeats. Using this assay, expansions were biochemically detected and subsequently quantified. We show that the occurence of expansions within these trinucleotide repeats is dependent upon...

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Identifiers

PMID: 9642087
DOI: 10.1006/jmbi.1998.1827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expansion of CTG repeats from human disease genes is dependent upon replication mechanisms in Escherichia coli: the effect of long patch mismatch repair revisited.PMID 9642087Read ↗

Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases.Semantic proximity Read ↗

Length of CTG.CAG repeats determines the influence of mismatch repair on genetic instability.Semantic proximity Read ↗

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The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions.Semantic proximity Read ↗

Environmental stress induces trinucleotide repeat mutagenesis in human cells.Semantic proximity Read ↗

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DM2 CCTG*CAGG repeats are crossover hotspots that are more prone to expansions than the DM1 CTG*CAG repeats in Escherichia coli.Semantic proximity Read ↗

Genetic instabilities of (CCTG).(CAGG) and (ATTCT).(AGAAT) disease-associated repeats reveal multiple pathways for repeat deletion.Semantic proximity Read ↗

Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.Semantic proximity Read ↗

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Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.Semantic proximity Read ↗

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