Article

Accurate prediction of CRISPR editing outcomes in somatic cell lines and zygote with few-shot learning

2024-11-11

Abstract excerpt

The CRISPR-Cas system has revolutionized gene editing, while its outcome prediction remains unsatisfactory, especially in new cell states due to their distinct DNA repair preferences. In this study, we introduce inDecay, a flexible system for predicting CRISPR editing outcomes from target sequence, returning probabilities of nearly the full spectrum of indel events. Uniquely, inDecay utilizes informative and param...

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Literature Corpus work: d20d864a-7573-5e28-b048-41a09e0c43a8
DOI: 10.1101/2024.11.08.622621

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