Article

Improved CRISPR/Cas9 Off-target Prediction with DNABERT and Epigenetic Features

2025-04-22

Abstract excerpt

CRISPR/Cas9 genome editing is a powerful tool in genetic engineering and gene therapy; however, off-target effects pose significant challenges for clinical applications. Accurate prediction of these unintended edits is crucial for ensuring safety and efficacy. In this study, we propose a novel approach that integrates DNABERT, a pre-trained DNA language model, with epigenetic features to improve off-target effect...

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Literature Corpus work: 3bb0f2fa-90b3-58b4-b161-e4fb8904a790
DOI: 10.1101/2025.04.16.649101

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