Article

Deep learning improves the ability of sgRNA off-target propensity prediction

2020-02-05

Abstract excerpt

<title>Abstract</title> <p>Background CRISPR/Cas9 system, as the third-generation genome editing technology, has been widely applied in target gene repair and gene expression regulation. Selection of appropriate sgRNA can improve the on-target knockout efficacy of CRISPR/Cas9 system with high sensitivity and specificity. However, when CRISPR/Cas9 system is operating, unexpected cleavage may occur at some sites, k...

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Literature Corpus work: dba9e14d-1229-5ca1-b67d-137adb3e17ce
DOI: 10.21203/rs.2.18444/v3

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