Article

BASCULE: Bayesian inference and clustering of mutational signatures leveraging biological priors

2024-09-20

Abstract excerpt

Mutational signatures provide key insights into cancer mutational processes, but the availability of signature catalogues generated by different groups using distinct methodologies underscores a need for standardisation. We introduce a Bayesian framework that offers a systematic approach to expanding existing signature catalogues for any type of mutational signature, while grouping patients based on shared signatu...

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Identifiers and source

Literature Corpus work: 17fa4afb-4bd3-514a-a38a-f9ef51617426
DOI: 10.1101/2024.09.16.613266

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