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Article

A comprehensive comparison of tools for fitting mutational signatures.

Nature communications - 2 Nov 2024

Medo Matúš, Ng Charlotte K Y, Medová Michaela

Abstract excerpt

Mutational signatures connect characteristic mutational patterns in the genome with biological or chemical processes that take place in cancers. Analysis of mutational signatures can help elucidate tumor evolution, prognosis, and therapeutic strategies. Although tools for extracting mutational signatures de novo have been extensively benchmarked, a similar effort is lacking for tools that fit known mutational...

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PMID: 39487150
DOI: 10.1038/s41467-024-53711-6
PMCID: PMC11530434

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