Article

Diffsig: Associating Risk Factors With Mutational Signatures

2023-02-10

Abstract excerpt

Somatic mutational signatures elucidate molecular vulnerabilities to therapy and therefore detecting signatures and classifying tumors with respect to signatures has clinical value. However, identifying the etiology of the mutational signatures remains a statistical challenge, with both small sample sizes and high variability in classification algorithms posing barriers. As a result, few signatures have been stron...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a50e9749-28a2-582b-b42c-7ec79baa99c5
DOI: 10.1101/2023.02.09.527740

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diffsig: Associating Risk Factors With Mutational SignaturesDOI 10.1101/2023.02.09.527740Read

Diffsig: Associating Risk Factors with Mutational Signatures.Semantic proximity Read

BASCULE: Bayesian inference and clustering of mutational signatures leveraging biological priorsSemantic proximity Read

Bayesian inference of cancer driver genes using signatures of positive selectionSemantic proximity Read

Relating mutational signature exposures to clinical data in cancers via signeR 2.0Semantic proximity Read

BASCULE: bayesian inference and clustering of mutational signatures leveraging biological priors.Semantic proximity Read

decompTumor2Sig: identification of mutational signatures active in individual tumorsSemantic proximity Read

Relating mutational signature exposures to clinical data in cancers via signeR 2.0.Semantic proximity Read

Accurate and sensitive mutational signature analysis with MuSiCalSemantic proximity Read

Detecting presence of mutational signatures in cancer with confidenceSemantic proximity Read

Accurate and sensitive mutational signature analysis with MuSiCal.Semantic proximity Read

A Dirichlet-multinomial mixed model for determining differential abundance of mutational signaturesSemantic proximity Read

Building a genetic and epigenetic predictive model of breast cancer intrinsic subtypes using large-scale data and hierarchical structure learningSemantic proximity Read