Article
Relating mutational signature exposures to clinical data in cancers via signeR 2.0.
BMC bioinformatics - 22 Nov 2023
Drummond Rodrigo D, Defelicibus Alexandre, Meyenberg Mathilde, Valieris Renan, Dias-Neto Emmanuel, Rosales Rafael A, da Silva Israel Tojal
Abstract excerpt
BACKGROUND: Cancer is a collection of diseases caused by the deregulation of cell processes, which is triggered by somatic mutations. The search for patterns in somatic mutations, known as mutational signatures, is a growing field of study that has already become a useful tool in oncology. Several algorithms have been proposed to perform one or both the following two tasks: (1) de novo estimation of signatures...
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