Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells.

Nucleic acids research - 18 Feb 2016

Anvar Zahra, Cammisa Marco, Riso Vincenzo, Baglivo Ilaria, Kukreja Harpreet, Sparago Angela, Girardot Michael, Lad Shraddha, De Feis Italia, Cerrato Flavia, Angelini Claudia, Feil Robert, Pedone Paolo V, Grimaldi Giovanna, Riccio Andrea

Abstract excerpt

Imprinting Control Regions (ICRs) need to maintain their parental allele-specific DNA methylation during early embryogenesis despite genome-wide demethylation and subsequent de novo methylation. ZFP57 and KAP1 are both required for maintaining the repressive DNA methylation and H3-lysine-9-trimethylation (H3K9me3) at ICRs. In vitro, ZFP57 binds a specific hexanucleotide motif that is enriched at its genomic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Immunoprecipitation
Share to Genomic Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Lysine

Share to Methylation

Share to Mouse Embryonic Stem Cells

Share to Nucleotide Motifs

Share to Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26481358
DOI: 10.1093/nar/gkv1059
PMCID: PMC4756812

Genes

ZFP57

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells.PMID 26481358Read ↗

In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control RegionsSemantic proximity Read ↗

Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain.Semantic proximity Read ↗

Epigenetic regulation of unique genes and repetitive elements by the KRAB zinc finger protein ZFP57Semantic proximity Read ↗

Human and mouse ZFP57 proteins are functionally interchangeable in maintaining genomic imprinting at multiple imprinted regions in mouse ES cells.Semantic proximity Read ↗

The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.Semantic proximity Read ↗

Zfp57 mutant ES cell lines directly derived from blastocysts.Semantic proximity Read ↗

ZFP57 dictates allelic expression switch of target imprinted genes.Semantic proximity Read ↗

Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.Semantic proximity Read ↗

Genomic imprinting defect in Zfp57 mutant iPS cell lines.Semantic proximity Read ↗

Functional characterization of UHRF1 variants in facilitating DNA methylation.Semantic proximity Read ↗

The embryonic DNA methylation program modulates the <i>cis-</i> regulatory landscape via CTCF antagonismSemantic proximity Read ↗

Proteins involved in establishment and maintenance of imprinted methylation marksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.