Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.

Nucleic acids research - 18 Nov 2020

Monteagudo-Sánchez Ana, Hernandez Mora Jose Ramon, Simon Carlos, Burton Adam, Tenorio Jair, Lapunzina Pablo, Clark Stephen, Esteller Manel, Kelsey Gavin, López-Siguero Juan Pedro, de Nanclares Guiomar Perez, Torres-Padilla Maria-Elena, Monk David

Abstract excerpt

Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation that is resistant to embryonic reprogramming, resulting in parental origin-specific monoallelic gene expression. A subset of individuals affected by imprinting disorders (IDs) displays multi-locus imprinting disturbances (MLID), which may result from aberrant establishment of imprinted differentially methylated regions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Beckwith-Wiedemann Syndrome
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Genomic Imprinting

Share to Germ Cells

Share to Microarray Analysis

Share to Pseudohypoparathyroidism

Share to RNA-Seq

Source

Open in PubMed Open full text

Identifiers

PMID: 33053156
DOI: 10.1093/nar/gkaa837
PMCID: PMC7672439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.PMID 33053156Read ↗

Epigenetic regulation of unique genes and repetitive elements by the KRAB zinc finger protein ZFP57Semantic proximity Read ↗

Human and mouse ZFP57 proteins are functionally interchangeable in maintaining genomic imprinting at multiple imprinted regions in mouse ES cells.Semantic proximity Read ↗

A KRAB domain zinc finger protein in imprinting and disease.Semantic proximity Read ↗

Proteins involved in establishment and maintenance of imprinted methylation marksSemantic proximity Read ↗

Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain.Semantic proximity Read ↗

Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.Semantic proximity Read ↗

A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints.Semantic proximity Read ↗

In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control RegionsSemantic proximity Read ↗

ZFP57 dictates allelic expression switch of target imprinted genes.Semantic proximity Read ↗

ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells.Semantic proximity Read ↗

Genome-wide allelic methylation analysis reveals disease-specific susceptibility to multiple methylation defects in imprinting syndromes.Semantic proximity Read ↗

Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.