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Article

Structural diversity of heat-sensing channel TRPV3 with Olmsted syndrome mutations.

Nature communications - 20 Jun 2026

Khau Jeffrey, Purohit Rutambhara, Nadezhdin Kirill D, Talyzina Irina A, Sobolevsky Alexander I

Abstract excerpt

Mutations in TRPV3, a temperature-sensitive ion channel critical for skin physiology, cause severe genodermatosis called Olmsted syndrome (OS). Here we integrate single-channel recordings and cryo-EM to characterize five OS mutants. All exhibit reduced temperature sensitivity in the temperature range relevant to normal skin physiology and disrupt structural elements stabilizing non-conducting states, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42323291
DOI: 10.1038/s41467-026-74687-5
PMCID: PMC13439195

Genes

TRPV3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Structural diversity of heat-sensing channel TRPV3 with Olmsted syndrome mutations.PMID 42323291Read ↗

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