Article

Efficacy of DNA Intercalator-Conjugated Triplex-Forming Oligonucleotide for Anticancer Therapy

2025-04-24

Abstract excerpt

A triplex-forming oligonucleotide (TFO) can form a sequence-specific triple helix via Hoogsteen hydrogen bonding to polypurine tracts within a major groove side of a DNA duplex. Triplex formation can induce a double-strand break, and this phenomenon at the amplified gene loci can selectively induce the cell death of cancer cells with specific gene amplification. However, the relationship between the binding affini...

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Literature Corpus work: 17d127f9-d474-5636-99dd-ed493d60fa10
DOI: 10.20944/preprints202504.2034.v1

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