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Article

Improved Aptamers for the Diagnosis and Potential Treatment of HER2-Positive Cancer

19 May 2016

Abstract excerpt

Aptamers provide a potential source of alternative targeting molecules for existing antibody diagnostics and therapeutics. In this work, we selected novel DNA aptamers targeting the HER2 receptor by an adherent whole-cell SELEX approach. Individual aptamers were identified by next generation sequencing and bioinformatics analysis. Two aptamers, HeA2_1 and HeA2_3, were shown to bind the HER2 protein with...

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Share to Advanced biosensing and bioanalysis techniques
Share to Monoclonal and Polyclonal Antibodies Research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27213406
DOI: 10.3390/ph9020029

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