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Involvement of the HER2 pathway in repair of DNA damage produced by chemotherapeutic agents

1 Nov 2009

Abstract excerpt

HER2 (ErbB2) is overexpressed in up to 30% of human breast cancers. Preclinical and clinical studies suggest synergy between some chemotherapeutic agents and the humanized anti-HER2 antibody trastuzumab (Herceptin). This study investigated the effects of etoposide and cisplatin on the repair of DNA damage in breast cancer cell lines. We examined the potential significance of HER2 nuclear expression in DNA repair....

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PMID: 19887555
DOI: 10.1158/1535-7163.mct-09-0219

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