Article

Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

2018-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Systemic amyloidosis represents a class of disorders in which misfolded proteins are secreted by effector organs and deposited as proteotoxic aggregates at downstream target tissues. Despite being well-described clinically, the contribution of effector organs such as the liver to the pathogenesis of these diseases is poorly understood. Here, we utilize a patient-specific induced pluripotent stem...

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Literature Corpus work: cb13eee8-ea90-5cfb-8375-0ebaf0c98210
DOI: 10.1101/358515

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