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Article

Examination of Skeletal and Senescence Phenotypes in Young Mice with Juvenile Onset Type 1 Diabetes.

Calcified tissue international - 1 Jul 2025

Kaur Japneet, Brooks Hannah W, Froemming Mitchell N, Cusick Nicholas C, Funk Janet L, Farr Joshua N

Abstract excerpt

Type 1 diabetes (T1D) and T2D are associated with skeletal fragility, contributing to increased fracture risk. Whereas decreased bone mineral density (BMD) is common in T1D, individuals with T2D tend to have normal or elevated BMD. These differences are incompletely understood but may stem from distinct mechanisms. Previously, we showed that obese male C57BL/6 mice (7-month-old) with T2D exhibit poor bone quality...

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Identifiers

PMID: 40593312
DOI: 10.1007/s00223-025-01401-w
PMCID: PMC12888753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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