Article
ImmuSeeker: deep mining of immune-related gene family signatures through lineage reconstruction.
Genome biology - 26 Mar 2026
Jiang Limin, Hurwitz Ivy, Wylezinski Lukasz S, Racke Michael K, Yan Fengyao, Ye Fei, Sheng Quanhu, Leng Shuguang, Chung Cecilia P, Stein C Michael, Li Chung-I, Kumar Naresh, Ceccarelli Michele, Baker Steven F, Perkins Douglas J, Spurlock Charles F, Han Leng, Guo Yan
Abstract excerpt
HLA typing from sequencing data is crucial for studying immune gene families, but high allele similarity challenges existing tools. We present ImmuSeeker, comprehensive software for extracting HLA genotypes, expression, and diversity at gene, one-field, and two-field allele levels, with improved Bayesian zygosity inference and graphical phylogenetic visualization. ImmuSeeker was benchmarked against nine...
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