Article

CART-GPT: A T Cell-Informed AI Linguistic Framework for Interpreting Neurotoxicity and Therapeutic Outcomes in CAR-T Therapy

2025-08-12

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy holds transformative potential for hematologic malignancies, yet predicting patient-specific treatment efficacy and neurotoxicity remains a major clinical challenge due to the complex and heterogeneous nature of the infused CAR-T cell populations. Here, we introduce CART-GPT, a transformer-based model fine-tuned on a curated atlas of 1.12 million CAR-T single-cell RNA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6068582-97fe-5f73-a342-de9f30aee7ce
DOI: 10.1101/2025.08.08.669387

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CART-GPT: A T Cell-Informed AI Linguistic Framework for Interpreting Neurotoxicity and Therapeutic Outcomes in CAR-T TherapyDOI 10.1101/2025.08.08.669387Read

CAR T cell foundation model predicts immunotherapy responseSemantic proximity Read

Projecting single-cell transcriptomics data onto a reference T cell atlas to interpret immune responsesSemantic proximity Read

Single-cell foundation models predict durable CAR T response despite imperfect cell annotationSemantic proximity Read

TSTScope Unifies Single-Cell Multi-Omics to Identify Functional T Cell States Predictive of Immunotherapy ResponseSemantic proximity Read

Deconvolution of clinical variance in CAR-T cell pharmacology and responseSemantic proximity Read

Integrative AI-Enabled Virtual Cell Modeling Reveals a Clinically Relevant Latent Effector State of Human CD8⁺ T Cells Undetectable by Conventional AnalysesSemantic proximity Read

An open CAR-T single-cell atlas to enable in-depth characterization and rational engineering of CAR-T productsSemantic proximity Read

Generalizable AI predicts immunotherapy outcomes across cancers and treatmentsSemantic proximity Read

Functional diversification and dynamics of CAR-T cells in patients with B-ALLSemantic proximity Read

Deciphering and advancing CAR T-cell therapy with single-cell sequencing technologiesSemantic proximity Read

Sequential Single-Cell Transcriptional and Protein Marker Profiling Reveals TIGIT as a Marker of CD19 CAR-T Cell Dysfunction in Patients with Non-Hodgkin LymphomaSemantic proximity Read