Article

Focal Deletions of a Promoter Tether Activate the <i>IRX3</i> Oncogene in T Cell Acute Lymphoblastic Leukemia

2024-02-08

Abstract excerpt

Oncogenes can be activated in cis through multiple mechanisms including enhancer hijacking events and noncoding mutations that create enhancers or promoters de novo . These paradigms have helped parse somatic variation of noncoding cancer genomes, thereby providing a rationale to identify noncanonical mechanisms of gene activation. Here we describe a novel mechanism of oncogene activation whereby focal copy numb...

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Literature Corpus work: 173af6ed-6ae1-5c4f-8063-3c15787b4c5d
DOI: 10.1101/2024.02.06.579027

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Focal Deletions of a Promoter Tether Activate the <i>IRX3</i> Oncogene in T Cell Acute Lymphoblastic LeukemiaDOI 10.1101/2024.02.06.579027Read

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