Article
Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.
Nature medicine - 26 Feb 2012
Della Gatta Giusy, Palomero Teresa, Perez-Garcia Arianne, Ambesi-Impiombato Alberto, Bansal Mukesh, Carpenter Zachary W, De Keersmaecker Kim, Sole Xavier, Xu Luyao, Paietta Elisabeth, Racevskis Janis, Wiernik Peter H, Rowe Jacob M, Meijerink Jules P, Califano Andrea, Ferrando Adolfo A
Abstract excerpt
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3. This systems biology analysis defined T cell leukemia homeobox 1 (TLX1) and TLX3 as master regulators of an oncogenic transcriptional circuit...
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