Article

Integrative construction of regulatory region networks in 127 human reference epigenomes by matrix factorization

2017-11-10

Abstract excerpt

Despite large experimental and computational efforts aiming to dissect the mechanisms underlying disease risk, mapping cis-regulatory elements to target genes remains a challenge. Here, we introduce a matrix factorization framework to integrate physical and functional interaction data of genomic segments. The framework was used to predict a regulatory network of chromatin interaction edges linking more than 20,000...

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Identifiers and source

Literature Corpus work: 17269c65-0e93-58cf-b9a0-5521fb5ea1b6
DOI: 10.1101/217588

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