Article

Polygenic Risk Scores and HLA Class II Variants are Biomarkers of Corticosteroid Response in Childhood Nephrotic Syndrome

2025-08-07

Abstract excerpt

<h4>Introduction</h4> Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there are currently no reliable predictors of therapy response at initial clinical presentation. <h4>Methods</h4> We conducted genome-wide association studie...

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Literature Corpus work: 1724680a-0a49-5984-a65e-09d69f3449e2
DOI: 10.1101/2025.08.01.25332825

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