Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population.

doi:10.1681/ASN.2017080859

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Article

Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population.

Journal of the American Society of Nephrology : JASN - 1 Aug 2018

Jia Xiaoyuan, Horinouchi Tomoko, Hitomi Yuki, Shono Akemi, Khor Seik-Soon, Omae Yosuke, Kojima Kaname, Kawai Yosuke, Nagasaki Masao, Kaku Yoshitsugu, Okamoto Takayuki, Ohwada Yoko, Ohta Kazuhide, Okuda Yusuke, Fujimaru Rika, Hatae Ken, Kumagai Naonori, Sawanobori Emi, Nakazato Hitoshi, Ohtsuka Yasufumi, Nakanishi Koichi, Shima Yuko, Tanaka Ryojiro, Ashida Akira, Kamei Koichi, Ishikura Kenji, Nozu Kandai, Tokunaga Katsushi, Iijima Kazumoto

Abstract excerpt

Background Nephrotic syndrome is the most common cause of chronic glomerular disease in children. Most of these patients develop steroid-sensitive nephrotic syndrome (SSNS), but the loci conferring susceptibility to childhood SSNS are mainly unknown.Methods We conducted a genome-wide association study (GWAS) in the Japanese population; 224 patients with childhood SSNS and 419 adult healthy controls were genotyped...

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PMID: 30012571
DOI: 10.1681/ASN.2017080859
PMCID: PMC6065083

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Source receipt: pubmed, retrieved 7 Sept 2026.

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