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Article

Steroid-resistant Nephrotic Syndrome in Children: A Mini-review on Genetic Mechanisms, Predictive Biomarkers and Pharmacotherapy Strategies.

Current pharmaceutical design - 1 Jan 2021

Guo Hong-Li, Li Ling, Xu Ze-Yue, Jing Xia, Xia Ying, Qiu Jin-Chun, Ji Xing, Chen Feng, Xu Jing, Zhao Fei

Abstract excerpt

Steroid-resistant nephrotic syndrome (SRNS) constitutes the second most frequent cause of chronic kidney disease in childhood. The etiology of SRNS remains largely unknown and no standardized treatment exists. Recent advances in genomics have helped to build understanding of the molecular mechanisms and pathogenesis of the disease. The genetic polymorphisms in genes encoding proteins which are involved in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33138756
DOI: 10.2174/1381612826666201102104412

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