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Article

Polygenic risk score from steroid-sensitive nephrotic syndrome GWAS indicates overlapping genetic basis with steroid-resistant cases.

Scientific reports - 3 Feb 2026

Wang Cong, Yin Guotao, Zhou Yidi, Song Yingchao, Tian Minle, Wang Xiaoyuan, Wang Jing, Li Qian, Zang Ruixian, Yang Zhenle, Yu Lichun, Liu Suwen, Wang Li, Yao Xiujun, Zhou Aihua, Chang Xiao, Sun Shuzhen

Abstract excerpt

Pediatric idiopathic nephrotic syndrome (INS) includes steroid-sensitive (SSNS) and steroid-resistant (SRNS) forms, which differ in treatment response and prognosis. We constructed a polygenic risk score (PRS) using summary statistics from the largest pediatric SSNS GWAS meta-analysis (2,440 cases and 36,023 controls) and evaluated it in an independent Chinese cohort of 2,507 controls, 123 SRNS patients, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41634105
DOI: 10.1038/s41598-026-38189-0
PMCID: PMC12921264

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INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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