HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.

doi:10.1681/ASN.2014030247

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Article

HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.

Journal of the American Society of Nephrology : JASN - 1 Jul 2015

Gbadegesin Rasheed A, Adeyemo Adebowale, Webb Nicholas J A, Greenbaum Larry A, Abeyagunawardena Asiri, Thalgahagoda Shenal, Kale Arundhati, Gipson Debbie, Srivastava Tarak, Lin Jen-Jar, Chand Deepa, Hunley Tracy E, Brophy Patrick D, Bagga Arvind, Sinha Aditi, Rheault Michelle N, Ghali Joanna, Nicholls Kathy, Abraham Elizabeth, Janjua Halima S, Omoloja Abiodun, Barletta Gina-Marie, Cai Yi, Milford David D, O'Brien Catherine, Awan Atif, Belostotsky Vladimir, Smoyer William E, Homstad Alison, Hall Gentzon, Wu Guanghong, Nagaraj Shashi, Wigfall Delbert, Foreman John, Winn Michelle P

Abstract excerpt

Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases of nephrotic syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure. Hypothesizing that coding variation may underlie SSNS risk, we conducted an exome array association study of SSNS. We enrolled a discovery set of 363 persons (214 South Asian children with SSNS and 149 controls) and genotyped them using the...

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PMID: 25349203
DOI: 10.1681/ASN.2014030247
PMCID: PMC4483579

Genes

PLCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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