Article
Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome.
Nature communications - 29 Apr 2023
Barry Alexandra, McNulty Michelle T, Jia Xiaoyuan, Gupta Yask, Debiec Hanna, Luo Yang, Nagano China, Horinouchi Tomoko, Jung Seulgi, Colucci Manuela, Ahram Dina F, Mitrotti Adele, Sinha Aditi, Teeninga Nynke, Jin Gina, Shril Shirlee, Caridi Gianluca, Bodria Monica, Lim Tze Y, Westland Rik, Zanoni Francesca, Marasa Maddalena, Turudic Daniel, Giordano Mario, Gesualdo Loreto, Magistroni Riccardo, Pisani Isabella, Fiaccadori Enrico, Reiterova Jana, Maringhini Silvio, Morello William, Montini Giovanni, Weng Patricia L, Scolari Francesco, Saraga Marijan, Tasic Velibor, Santoro Domenica, van Wijk Joanna A E, Milošević Danko, Kawai Yosuke, Kiryluk Krzysztof, Pollak Martin R, Gharavi Ali, Lin Fangmin, Simœs E Silva Ana Cristina, Loos Ruth J F, Kenny Eimear E, Schreuder Michiel F, Zurowska Aleksandra, Dossier Claire, Ariceta Gema, Drozynska-Duklas Magdalena, Hogan Julien, Jankauskiene Augustina, Hildebrandt Friedhelm, Prikhodina Larisa, Song Kyuyoung, Bagga Arvind, Cheong Hae, Ghiggeri Gian Marco, Vachvanichsanong Prayong, Nozu Kandai, Lee Dongwon, Vivarelli Marina, Raychaudhuri Soumya, Tokunaga Katsushi, Sanna-Cherchi Simone, Ronco Pierre, Iijima Kazumoto, Sampson Matthew G
Abstract excerpt
Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is the most common childhood glomerular disease. Previous genome-wide association studies (GWAS) identified a risk locus in the HLA Class II region and three additional independent risk loci. But the genetic architecture of pSSNS, and its genetically driven pathobiology, is largely unknown. Here, we conduct a multi-population GWAS meta-analysis in 38,463...
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