Machine learning modeling of protein-intrinsic features predicts tractability of targeted protein degradation

Abstract excerpt

Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery. However, the susceptibility of proteins for targeting by TPD approaches, termed “degradability”, is largely unknown. Recent systematic studies to map the degradable kinome have shown differences in degradation between kinas...

Topics

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• Mutation
• Neoplasms
• Phosphorylation
• Proteasome Endopeptidase Complex
• Protein Kinase Inhibitors
• Protein Kinases
• Proteolysis
• Proteome

Identifiers and source

Literature Corpus work

170e44ed-5392-5b84-b8cb-4a50dad058db

DOI

10.1101/2021.09.27.462040